Pharmacokinetic-pharmacodynamic modeling and simulation by Peter L Bonate, SpringerLink

Pharmacokinetic-pharmacodynamic modeling and simulation Peter L Bonate, SpringerLink ebook
ISBN: 0387271996, 9780387271996
Format: pdf
Publisher: Springer
Page: 394

A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. Bonate Publisher:Springer ISBN:139939399X ISBN33: Date3116-31-31. Population Pharmacokinetic/Pharmacodynamic Modeling of Clopidogrel in Korean Healthy Volunteers and Stroke Patients. Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. By providing this infrastructure Devidas believes the partners can maximise the usefulness of pharmacokinetic/pharmacodynamic modeling and simulation (M&S) and increase its value in the drug development process. Joomi Lee, MS; Yangha Hwang Financial disclosure: This research was supported by the Korea National Enterprise for Clinical Trials, a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, the Republic of South Korea (A070001), and by the Pfizer Modeling & Simulation Education Center in Korea (PMECK). One of the authoritative texts on the subject. WW 168 Op615 2012; The Oxford handbook of the history of medicine edited by Mark Jackson WZ 40 Ox982 2011; Pharmacokinetic-pharmacodynamic modeling and simulation Peter L. Pharmacokinetic-pharmacodynamic (PK-PD) modeling has emerged as a major tool in clinical pharmacology to optimize drug use by designing rational dosage forms and dosage regimes. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting within-host parasite response was performed. Cognigen Corporation provides strategic pharmacology and pharmacometric consulting services, PK/PD model development with NONMEM, clinical trial simulations, exposure-response evaluations, dose justification strategies and The 3-day workshop will be preceded by Pharmacokinetic–Pharmacodynamic Modeling: Concepts and Applications, a workshop presented by William J. A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters. Title:Pharmacokinetic-Pharmacodynamic Modeling and Simulation Author:Peter L. Quantitative representation of the dose-concentration- response relationship should provide PK-PD simulations allow the assessment of the descriptive parameters as the functions of dose and dose rate.